Hemizygosity Enables a Mutational Transition Governing Fungal Virulence and Commensalism
نویسندگان
چکیده
منابع مشابه
Evolutionary Transition from Pathogenicity to Commensalism: Global Regulator Mutations Mediate Fitness Gains through Virulence Attenuation
Symbiotic interactions are indispensable for metazoan function, but their origin and evolution remain elusive. We use a controlled evolution experiment to demonstrate the emergence of novel commensal interactions between Pseudomonas aeruginosa, an initially pathogenic bacterium, and a metazoan host, Caenorhabditis elegans. We show that commensalism evolves through loss of virulence, because it ...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2019
ISSN: 1931-3128
DOI: 10.1016/j.chom.2019.01.005